Potential effects combined with PDGF, VEGF, bFGF, and TGF-1 for acute and chronic wounds as they promote the healing effect, inducing angiogenesis, migration, proliferation, and modulating the inflammatory response and ROS production. EGCG, delphinidin, or -carotene has a possible effect within the regulation of inflammatory agents and ROS, as well as the modulation of collagen production and remodelling for burns and hypertrophic scarring wounds. Microenvironment aspects (eg, enzymes, UV, pH) degrade development factors and antioxidants diminishing their effect. Particulate automobiles (eg, nanoparticles and microparticles) boost bioactive bioavailability and stability, hence enhancing their effect. They can be embedded in wound dressings, which includes fibres, hydrogels, or microneedles. They’re expected to block pathogens, supply an sufficient wound microenvironment (eg, moisture, pH), and absorb exudate that should really market wound healing. Further studies ought to be focused on characterising the proposed growth factor–antioxidant combinations to confirm their synergistic effect on the wound healing process. Furthermore, research focused on the optimisation of growth factor-antioxidant combination ratios are relevant to have a much better understanding about the rational choice of bioactive principles for wound healing applications. ACK NO WLE DGE Men TS PVM, MLS, and JB structured and contributed in equal components inside the post. PVM drew the figure. MLS and JB are corresponding authors. MLS is a member of CONICET. Analysis was funded by Consejo Nacional de Ciencia y Tecnolog (1048769). CONFLICT OF INTEREST The other authors declare no conflicts of interest concerning the publication of this article. Data AVAILABILITY STATEMENT Information openly accessible in a public repository that issues datasets with DOIs ORCID Pamela Via -Mendieta https://orcid.org/0000-00032975-8440 Mirna Lorena Snchez https://orcid.org/FGFR Proteins Biological Activity 0000-0002a 1372-4169 Jorge Benavides https://orcid.org/0000-0002-9579-483X R EF E RE N C E S1. ‘Izzah Ibrahim N, Wong SK, Mohamed IN, et al. Wound healing properties of chosen organic solutions. Int J Environ Res Public Wellness. 2018;15(11):2360.two. Tottoli EM, Dorati R, Genta I, Chiesa E, Pisani S, Conti B. Skin wound healing method and new emerging technologies for skin wound care and regeneration. Pharmaceutics. 2020; 12:1-30. three. Zarei F, Soleimaninejad M. Role of development elements and biomaterials in wound healing. Artif Cells Nanomed Biotechnol. 2018;46:906-911. 4. Shah A, Amini-Nik S. The role of phytochemicals within the inflammatory phase of wound healing. Int J Mol Sci. 2017; 18(5):1068. five. Aldag C, Nogueira Teixeira D, Leventhal PS. Skin rejuvenation employing cosmetic merchandise containing development components, cytokines, and matrikines: a review in the literature. Clin Cosmet Investig Dermatol. 2016;9:411-419. 6. Barrientos S, Stojadinovic O, Golinko MS, Brem H, TomicCanic M. Development components and cytokines in wound healing. Wound Repair Regen. 2008;16:585-601. 7. Yamakawa S, Hayashida K. Advances in surgical applications of growth aspects for wound healing. Burn Trauma. 2019;7: 1-13. 8. Zeitter S, Sikora Z, Jahn S, et al. Microneedling: matching the outcomes of health-related needling and repetitive treatment Gastric Inhibitory Peptide (GIP) Proteins Formulation options to maximize prospective for skin regeneration. Burns. 2014;40:966-973. 9. Pastore S, Lulli D, Fidanza P, et al. Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal grow.
