Product Name :
[pTyr1150/Tyr1151]Insulin receptor monoclonal antibody (10C3)
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Stable at -20°C up to 1 year.
Description:
The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes. Western blot analysis of untreated (1) or insulin-stimulated (2) MCA-MB-213 cancer cells probed with Insulin Receptor (pTyr1150/1151) mAb (10C3).{{2101538-28-5} web|{2101538-28-5} Protocol|{2101538-28-5} Formula|{2101538-28-5} supplier} Western blot analysis of untreated (1) or insulin-stimulated (2) MCA-MB-213 cancer cells probed with Insulin Receptor (pTyr1150/1151) mAb (10C3).{{2101700-15-4} medchemexpress|{2101700-15-4} Technical Information|{2101700-15-4} Purity|{2101700-15-4} custom synthesis}
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| Alternative Name INSR | Application ELISA, WB | Clone 10C3 | Crossreactivity Cross-reacts with IGF1 receptor.PMID:28613663 | Formulation Liquid. In PBS containing 50% glycerol, PEG, sucrose, and 0.09% sodium azide. | Host Mouse | Immunogen Synthetic peptide corresponding to a portion of human Insulin Receptor phosphorylated at Tyr1150/1151, conjugated to KLH. | Isotype IgG1 | Recommendation Dilutions/Conditions ELISA (0.1µg/ml)Western Blot (0.2-0.5µg/ml, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Species Reactivity Human | UniProt ID P06213 | Unit of Measure (UM) µg
