Product Name :
Phe-Met-Arg-Phe, amide
Description:
Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.
CAS:
64190-70-1
Molecular Weight:
598.76
Formula:
C29H42N8O4S
Chemical Name:
(2S)-2-[(2S)-2-[(2S)-2-amino-3-phenylpropanamido]-4-(methylsulfanyl)butanamido]-N-[(1S)-1-carbamoyl-2-phenylethyl]-5-[(diaminomethylidene)amino]pentanamide
Smiles :
CSCC[C@H](NC(=O)[C@@H](N)CC1C=CC=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1C=CC=CC=1)C(N)=O
InChiKey:
WCSPDMCSKYUFBX-ZJZGAYNASA-N
InChi :
InChI=1S/C29H42N8O4S/c1-42-16-14-23(35-26(39)21(30)17-19-9-4-2-5-10-19)28(41)36-22(13-8-15-34-29(32)33)27(40)37-24(25(31)38)18-20-11-6-3-7-12-20/h2-7,9-12,21-24H,8,13-18,30H2,1H3,(H2,31,38)(H,35,39)(H,36,41)(H,37,40)(H4,32,33,34)/t21-,22-,23-,24-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.|Product information|CAS Number: 64190-70-1|Molecular Weight: 598.76|Formula: C29H42N8O4S|Chemical Name: (2S)-2-[(2S)-2-[(2S)-2-amino-3-phenylpropanamido]-4-(methylsulfanyl)butanamido]-N-[(1S)-1-carbamoyl-2-phenylethyl]-5-[(diaminomethylidene)amino]pentanamide|Smiles: CSCC[C@H](NC(=O)[C@@H](N)CC1C=CC=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1C=CC=CC=1)C(N)=O|InChiKey: WCSPDMCSKYUFBX-ZJZGAYNASA-N|InChi: InChI=1S/C29H42N8O4S/c1-42-16-14-23(35-26(39)21(30)17-19-9-4-2-5-10-19)28(41)36-22(13-8-15-34-29(32)33)27(40)37-24(25(31)38)18-20-11-6-3-7-12-20/h2-7,9-12,21-24H,8,13-18,30H2,1H3,(H2,31,38)(H,35,39)(H,36,41)(H,37,40)(H4,32,33,34)/t21-,22-,23-,24-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Hoechst 33342} site|{Hoechst 33342} Autophagy|{Hoechst 33342} Biological Activity|{Hoechst 33342} Purity|{Hoechst 33342} custom synthesis|{Hoechst 33342} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Clindamycin palmitate} web|{Clindamycin palmitate} Antibiotic|{Clindamycin palmitate} Technical Information|{Clindamycin palmitate} In Vitro|{Clindamycin palmitate} custom synthesis|{Clindamycin palmitate} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33679749 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe, amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (pIn Vivo:|Phe-Met-Arg-Phe, amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min.|Products are for research use only. Not for human use.|
