Product Name :
PAR-4 Agonist Peptide, amide
Description:
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
CAS:
352017-71-1
Molecular Weight:
680.79
Formula:
C34H48N8O7
Chemical Name:
(Z,2S)-6-amino-2-[(Z)-{2-[(Z)-{[(2S)-1-[(2S)-2-[(Z)-[(2S)-2-amino-1-hydroxypropylidene]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino]-1-hydroxyethylidene}amino]-N-[(1S)-1-(C-hydroxycarbonimidoyl)-2-phenylethyl]hexanimidic acid
Smiles :
C[C@H](N)/C(/O)=N/[C@@H](CC1C=CC(O)=CC=1)C(=O)N1CCC[C@H]1/C(/O)=N/C/C(/O)=N/[C@@H](CCCCN)/C(/O)=N/[C@@H](CC1C=CC=CC=1)C(=N)O
InChiKey:
BBAOHIALRKLBRD-OZDPOCAXSA-N
InChi :
InChI=1S/C34H48N8O7/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46)/t21-,25-,26-,27-,28-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Indole-3-carbinol} MedChemExpress|{Indole-3-carbinol} Metabolic Enzyme/Protease|{Indole-3-carbinol} Biological Activity|{Indole-3-carbinol} Purity|{Indole-3-carbinol} custom synthesis|{Indole-3-carbinol} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{Ondansetron} site|{Ondansetron} Neuronal Signaling|{Ondansetron} Biological Activity|{Ondansetron} Description|{Ondansetron} supplier|{Ondansetron} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23443926
Additional information:
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.|Product information|CAS Number: 352017-71-1|Molecular Weight: 680.79|Formula: C34H48N8O7|Chemical Name: (Z,2S)-6-amino-2-[(Z)-{2-[(Z)-{[(2S)-1-[(2S)-2-[(Z)-[(2S)-2-amino-1-hydroxypropylidene]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino]-1-hydroxyethylidene}amino]-N-[(1S)-1-(C-hydroxycarbonimidoyl)-2-phenylethyl]hexanimidic acid|Smiles: C[C@H](N)/C(/O)=N/[C@@H](CC1C=CC(O)=CC=1)C(=O)N1CCC[C@H]1/C(/O)=N/C/C(/O)=N/[C@@H](CCCCN)/C(/O)=N/[C@@H](CC1C=CC=CC=1)C(=N)O|InChiKey: BBAOHIALRKLBRD-OZDPOCAXSA-N|InChi: InChI=1S/C34H48N8O7/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46)/t21-,25-,26-,27-,28-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (PProducts are for research use only. Not for human use.|
