Product Name :
Wogonin
Description:
Wogonin, a flavonoid isolated from Scutellaria baicalensis Georgi, exhibits potent anti-tumor effects in vivo and in vitro.
CAS:
632-85-9
Molecular Weight:
284.26
Formula:
C16H12O5
Chemical Name:
4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-
Smiles :
COC1=C2OC(=CC(=O)C2=C(O)C=C1O)C1C=CC=CC=1
InChiKey:
XLTFNNCXVBYBSX-UHFFFAOYSA-N
InChi :
InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Wogonin, a flavonoid isolated from Scutellaria baicalensis Georgi, exhibits potent anti-tumor effects in vivo and in vitro.|Product information|CAS Number: 632-85-9|Molecular Weight: 284.26|Formula: C16H12O5|Chemical Name: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-|Smiles: COC1=C2OC(=CC(=O)C2=C(O)C=C1O)C1C=CC=CC=1|InChiKey: XLTFNNCXVBYBSX-UHFFFAOYSA-N|InChi: InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3|Technical Data|Appearance: Solid Power.{{A-966492} MedChemExpress|{A-966492} Epigenetics|{A-966492} Technical Information|{A-966492} In Vitro|{A-966492} custom synthesis|{A-966492} Cancer} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Wogonin (0-200 μM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells.{{Cidofovir} site|{Cidofovir} Cell Cycle/DNA Damage|{Cidofovir} Purity & Documentation|{Cidofovir} In stock|{Cidofovir} custom synthesis|{Cidofovir} Epigenetics} Wogonin (10-40 μM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8.PMID:24360118 Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 µM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells. Wogonin (1.25, 2.5, 5, 10, 20 μg/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells.|In Vivo:|Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model. Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-γ expression in mice with ALD and EtOH induced RAW264.7 cells.|References:|Zhao Y, Zhang L, Wu Y, Dai Q, Zhou Y, Li Z, Yang L, Guo Q, Lu N. Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53. Pharmacol Res. 2018 Jul 18;135:49-59. doi: 10.1016/j.phrs.2018.07.011. [Epub ahead of print] PubMed PMID: 30031170.Yang W, He S, Xiao N, Qiao Y, Sui H, Liang L, Chen J, Li W, Zhang L. Simultaneous Determination of 15 Flavonoids in Scutellaria barbata-Hedyotis diffusa Herb Pair by HPLC Q-TOF MS. J AOAC Int. 2018 Jul 20. doi: 10.5740/jaoacint.17-0469. [Epub ahead of print] PubMed PMID: 30029697.Go JH, Wei JD, Park JI, Ahn KS, Kim JH. Wogonin suppresses the LPS enhanced invasiveness of MDA MB 231 breast cancer cells by inhibiting the 5 LO/BLT2 cascade. Int J Mol Med. 2018 Jul 12. doi: 10.3892/ijmm.2018.3776. [Epub ahead of print] PubMed PMID: 30015917.Products are for research use only. Not for human use.|
