Product Name :
PA-824
Description:
Pretomanid, aslo known as PA-824, a bioreductive drug. PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC<1 microg/ml). PA-824 showed significant activity at 2, 10, and 50 microg/ml, similar to that of metronidazole, in a dose-dependent manner. PA-824's good activity in in vivo models, as well as its activity against multidrug-resistant M. tuberculosis and against M. tuberculosis isolates in a potentially latent state, makes PA-824 an attractive drug candidate for the therapy of tuberculosis.
CAS:
187235-37-6
Molecular Weight:
359.{{Pelabresib} medchemexpress|{Pelabresib} Epigenetics|{Pelabresib} Protocol|{Pelabresib} Description|{Pelabresib} supplier|{Pelabresib} Cancer} 26
Formula:
C14H12F3N3O5
Chemical Name:
(6S)-2-nitro-6-{[4-(trifluoromethoxy)phenyl]methoxy}-5H,6H,7H-imidazo[2,1-b][1,3]oxazine
Smiles :
[O-][N+](=O)C1=CN2C[C@@H](COC2=N1)OCC1C=CC(=CC=1)OC(F)(F)F
InChiKey:
ZLHZLMOSPGACSZ-NSHDSACASA-N
InChi :
InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Oxacillin sodium salt} MedChemExpress|{Oxacillin sodium salt} Antibiotic|{Oxacillin sodium salt} Technical Information|{Oxacillin sodium salt} In Vitro|{Oxacillin sodium salt} supplier|{Oxacillin sodium salt} Epigenetic Reader Domain}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Pretomanid, aslo known as PA-824, a bioreductive drug.PMID:23892746 PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MICProduct information|CAS Number: 187235-37-6|Molecular Weight: 359.26|Formula: C14H12F3N3O5|Chemical Name: (6S)-2-nitro-6-{[4-(trifluoromethoxy)phenyl]methoxy}-5H,6H,7H-imidazo[2,1-b][1,3]oxazine|Smiles: [O-][N+](=O)C1=CN2C[C@@H](COC2=N1)OCC1C=CC(=CC=1)OC(F)(F)F|InChiKey: ZLHZLMOSPGACSZ-NSHDSACASA-N|InChi: InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
