Product Name :
NSC305787
Description:
NSC305787 is an inhibitor of ezrin with a Kd of 5.85 μM, inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, has antitumor activity.
CAS:
785718-37-8
Molecular Weight:
445.42
Formula:
C25H30Cl2N2O
Chemical Name:
[2-(adamantan-1-yl)-6,8-dichloroquinolin-4-yl](piperidin-2-yl)methanol
Smiles :
OC(C1CCCCN1)C1=CC(=NC2=C1C=C(Cl)C=C2Cl)C12CC3CC(C1)CC(C2)C3
InChiKey:
YNGQUUFYBFKLNH-UHFFFAOYSA-N
InChi :
InChI=1S/C25H30Cl2N2O/c26-17-8-18-19(24(30)21-3-1-2-4-28-21)10-22(29-23(18)20(27)9-17)25-11-14-5-15(12-25)7-16(6-14)13-25/h8-10,14-16,21,24,28,30H,1-7,11-13H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NSC305787 is an inhibitor of ezrin with a Kd of 5.85 μM, inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, has antitumor activity.|Product information|CAS Number: 785718-37-8|Molecular Weight: 445.42|Formula: C25H30Cl2N2O|Chemical Name: [2-(adamantan-1-yl)-6,8-dichloroquinolin-4-yl](piperidin-2-yl)methanol|Smiles: OC(C1CCCCN1)C1=CC(=NC2=C1C=C(Cl)C=C2Cl)C12CC3CC(C1)CC(C2)C3|InChiKey: YNGQUUFYBFKLNH-UHFFFAOYSA-N|InChi: InChI=1S/C25H30Cl2N2O/c26-17-8-18-19(24(30)21-3-1-2-4-28-21)10-22(29-23(18)20(27)9-17)25-11-14-5-15(12-25)7-16(6-14)13-25/h8-10,14-16,21,24,28,30H,1-7,11-13H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 6 mg/mL (13.47 mM; Need ultrasonic and warming).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{CNTF Protein, Human} web|{CNTF Protein, Human} Biological Activity|{CNTF Protein, Human} Data Sheet|{CNTF Protein, Human} supplier|{CNTF Protein, Human} Epigenetics} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NSC305787 is an inhibitor of ezrin with a Kd of 5.{{Methoxsalen} web|{Methoxsalen} Cytochrome P450|{Methoxsalen} Technical Information|{Methoxsalen} References|{Methoxsalen} manufacturer|{Methoxsalen} Epigenetics} 85 μM, and has antitumor activity.PMID:24635174 NSC305787 inhibits PKCΙ phosphorylation of Ezrin, Moesin, Radixin, MBP, with IC50s of 8.3, 9.4, 55, 58.9 μM, respectively. NSC305787 binds to PKCΙ with a Kd value of 172.4 μM, and inhibits ezrin T567 phosphorylation primarily via its binding to ezrin and not through inhibition of PKCΙ kinase activity. NSC305787 (1, 10 μM) shows inhibitory activity against ezrin-mediated invasion of K7M2 osteosarcoma (OS) cells. Moreover, NSC305787 (10 μM) reduces cell motility phenotypes in zebrafish and blocks OS metastatic growth in lung organ culture.|In Vivo:|NSC305787 (0.240 mg/kg/day, i.p.) suppresses ezrin-dependent osteosarcoma metastatic growth in mouse lung. NSC305787 (240 μg/kg, i.p.) dramatically inhibits pulmonary metastasis in a transgenic mouse model of osteosarcoma (Osx-Cre+p53fl/flpRBfl/fl) and shows a more favorable pharmacokinetic profile compared with NSC668394 in the mouse model.|Products are for research use only. Not for human use.|
