, retention, and release profile, dispersibilityI III IIStage 4 Particle specification Delivery technique selectionParticle characteristics Loading traits Retention and release traits Environmental responsiveness Delivery technique selectionParticles, composition, concentration, morphology, dimensions, physico-chemical properties, charge interactions Loading capacity, encapsulation efficiency Prolonged, burst, or triggered release Ease of manufacture, expense, legal status, and consumer acceptability (plant-based/ vegetarian, animal-based, Kosher, or synthetic components) Micelles, liposomes, emulsions, microemulsion, nanoemulsion, solid lipid nanoparticles, or polymer particlesIIIIIStage five Process specificationIngredient excellent: Important ingredient attributes Manufacturing steps: Vital processing attributesComposition, high quality; ingredient properties/colloidal delivery technique efficiency interaction Sources, gear, and facilities readily available; price, simplicity, reliability, scale up; dissolution occasions, temperatures, mixing circumstances, appropriate particle size distribution.IPharmaceutics 2021, 13,20 ofTable three. Cont.Stage Procedure Home RequirementsICurcumin-Fortified Functional Beverage The particle size distribution with the nanoemulsions and their electrical qualities ( possible) could be measured by dynamic light scattering and particle electrophoresis, respectively Environmental pressure might be impacted by exposing it to ionic strength, distinctive pH and temperature, and mechanical circumstances Measuring the optical properties (colorimeter), rheology (rheometer), and phase separation (visual observation) of the functional beverage makes it possible for researchers to monitor the influence of your delivery system around the look, texture, and stability on the end-productStage 6 Functionality testingAnalytical tools Testing protocolsStatic and dynamic light scattering methods, microelectrophoresis, optical, confocal fluorescence, electron microscopy, colorimetry, spectrophotometry, chromatography, mass spectrometry, sensory tests In-product tests, accelerated screening tests, environmental anxiety testsI IStage 7 Program optimizationMonitoring and tabulating the traits with the delivery method and end-product all through its life cycle so as to optimize their properties and make appropriate adjustments exactly where doable, if neededPharmaceutics 2021, 13,21 ofThe DbD method has been tested on curcumin as a case study. Inside the reported case study, considering the fact that curcumin is actually a water-insoluble, low-molecular-weight, and crystalline constituent that can not be integrated into an aqueous-based functional beverage with out becoming dispersed in colloidal particles, it has been encapsulated to design a fortified nutritional drink just like the Ayurvedic “golden milk”. As this beverage seems cloudy, yellowish, and Calcium Channel Activator Accession creamy, oil-in-water nanoemulsion was chosen as the most suitable delivery method to attain the aim [54,106]. The range of functional food matrix exactly where curcumin could be incorporated is really wide and every food form has its own characteristics (bread, beverages, sauces, dressings, frozen meals, cereal bars), therefore, colloidal delivery systems should fulfill every single requirement in line with the end-product’s Calcium Channel Inhibitor medchemexpress variability. An overview with the main food-grade colloidal delivery systems that effectively encapsulate curcumin is offered under. Moreover, the latter, categorized as simple, delivery systems may very well be employed as creating blocks
