[23519] 69 [621] 661 [266220] 84 [3757] 1.350 [0.466.300] 54 (93.9) 4 (six.9) eight (6) 138 [9293] 64 [529] 101 [8223] 179 [15803] 488 [46015] 61.9 (11.four) 64 (46.7) 21 (15.three) 46 (33.6) 39 (28.five) 45 (34.1) 26 (19.7) 61 (46.2) 70 (51.1) three (two.2) 15 (10.9) 19 (13.9) 1 (0.7) 24.4 [29.6] 242 [20885] 87 [767] 893 [387025] 102 [4928] 2.200 [0.668.275] 135 (98.5) 13 (9.5) 7 (six) 133 [9026] 65 [528] 100 [8418] 181 [15102] 487 [45318] 0.33 1.00 0.54 0.13 1.00 0.21 0.02 0.001 0.71 0.35 0.38 0.07 0.76 0.23 0.98 0.91 0.89 0.90 0.81 0.001 0.25 0.32 0.01 0.85 0.45 Male individuals N = 137 P-valueFrontiers in Cardiovascular Medicine | frontiersin.orgOctober 2021 | Volume eight | ArticleTavenier et al.Sex Variations in Platelet ReactivityTABLE 1 | CDK16 web Continued Basic baseline qualities Female patients N = 58 Male individuals N = 137 P-valueMyocardial blush grade ( ) Unknown 0 1 two three Distal embolization ( ) Glycoprotein IIb/IIIa inhibitor ( ) None 6 hours infusion 12 hours infusion 24 hours infusion Electrocardiographic benefits Full ST-resolution ( ) Promptly following major PCI 1 hour just after key PCI six hours following major PCI0.92 3 (5.2) 1 (1.7) 2 (3.4) 9 (15.five) 43 (74.1) 4 (6.9) 48 (82.8) 4 (6.9) 5 (eight.6) 1 (1.7) ten (7.three) 4 (2.9) four (2.9) 26 (19.0) 93 (67.9) 7 (5.1) 111 (81.0) 19 (13.9) four (two.9) 3 (2.2) 0.74 0.26 (51) 31 (63.three) 40 (75.5)36 (31.six) 58 (46.four) 80 (67.2)0.08 0.23 0.BMI, body mass index; CAD, Aurora B Molecular Weight coronary artery disease; CABG, coronary artery bypass grafting; CK, creatine kinase; CK MB, creatine kinase myoglobin binding; IQR, interquartile range; PCI, percutaneous coronary intervention; SD, regular deviation, T1, just before main PCI; T2, right away following principal PCI; T3, 1-hour soon after primary PCI; T4, 6 hours just after key PCI; CAG, coronary angiography; LAD, left anterior descending artery; LM, left key vessel; POBA, plain old balloon angiography; PCI, percutaneous coronary intervention; RCA, ideal coronary artery; RCx, ramus circumflex artery; TIMI, Thrombolysis In Myocardial Infarction; PCI, percutaneous coronary intervention.TABLE 2 | Major and secondary outcomes on pharmacodynamics and inetics. Most important outcomes Female sufferers N = 58 Male sufferers N = 137 P-valuePRU (median, IQR) T1 T2 T3 T4 High platelet reactivity at T2 ( ) Ticagrelor concentration (median, IQR) T1 T2 T3 T4 Ticagrelor active metabolite concentration (median, IQR) T1 T2 T3 T4 Ticagrelor concentration total (median, IQR) T1 T2 T3 T174 [8627] 135 [4728] 45 [69] 13 [68] 17 (34.0) 141 [2591] 270 [7499] 474 [23804] 495 [28361] 12 [07] 34 [717] 93 [3512] 160 [9606] 150 [2555] 205 [8845] 556 [272099] 656 [39550]188 [12224] 160 [4019] 40 [727] 8 [43] 35 (30.7) 76 [1545] 163 [3714] 408 [17908] 321 [19637] four [02] 17 [02] 81 [2231] 92 [5434] 76 [1671] 188 [4368] 485 [20123] 431 [26432]0.75 0.92 0.60 0.33 0.81 0.049 0.09 0.13 0.001 0.04 0.049 0.09 0.001 0.05 0.09 0.12 0.univariable evaluation. IQR, interquartile variety; PRU, platelet reactivity units; T1, ahead of key PCI; T2, immediately just after major PCI; T3, 1-hour immediately after principal PCI; T4, six hours immediately after main PCI.(53.4 vs. 33.six , P = 0.01), and renal function based on creatinine levels (69 (IQR 621) vs. 87 (IQR 767), P 0.001). Female individuals skilled equivalent levels of discomfort at randomization when compared with males (eight out of 10 step pain scale (IQR 6) for females; 7 out of ten step discomfort scale (IQR six) for males; P = 0.23). The median times from arrival on the ambulance in the patient web page to arrival in the cathlab (64 minutes (529) vs. 65 minutes
