Product Name :
MPP dihydrochloride
Description:
MPP dihydrochloride is a highly selective estrogen receptor alpha (ERα) antagonist. MPP dihydrochloride reduces the ratio of p-ERα/ERα.
CAS:
911295-24-4
Molecular Weight:
542.50
Formula:
C29H33Cl2N3O3
Chemical Name:
4-[1-(4-hydroxyphenyl)-4-methyl-5-4-[2-(piperidin-1-yl)ethoxy]phenyl-2,3-dihydro-1H-pyrazol-3-ylidene]cyclohexa-2,5-dien-1-one dihydrochloride
Smiles :
Cl.Cl.CC1C(NN(C=1C1C=CC(=CC=1)OCCN1CCCCC1)C1C=CC(O)=CC=1)=C1C=CC(=O)C=C1
InChiKey:
SMPRQALBFACGGO-UHFFFAOYSA-N
InChi :
InChI=1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,30,34H,2-4,17-20H2,1H3;2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MPP dihydrochloride is a highly selective estrogen receptor alpha (ERα) antagonist. MPP dihydrochloride reduces the ratio of p-ERα/ERα.|Product information|CAS Number: 911295-24-4|Molecular Weight: 542.50|Formula: C29H33Cl2N3O3|Chemical Name: 4-[1-(4-hydroxyphenyl)-4-methyl-5-4-[2-(piperidin-1-yl)ethoxy]phenyl-2,3-dihydro-1H-pyrazol-3-ylidene]cyclohexa-2,5-dien-1-one dihydrochloride|Smiles: Cl.Cl.CC1C(NN(C=1C1C=CC(=CC=1)OCCN1CCCCC1)C1C=CC(O)=CC=1)=C1C=CC(=O)C=C1|InChiKey: SMPRQALBFACGGO-UHFFFAOYSA-N|InChi: InChI=1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,30,34H,2-4,17-20H2,1H3;2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Spectinomycin manufacturer |Shelf Life: ≥12 months if stored properly.Lopinavir Autophagy |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32657941 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MPP (1, 5, 10, 25, 50 and 100 µM; 24 h) decreases cell viability with an IC50 value of 20.01 µM in RL95-2 cells. MPP dihydrochloride shows antiproliferative activity at a concentration of 10 μM in RL95-2 cells. MPP dihydrochloride (20 µM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα.|In Vivo:|MPP (Low dose 20 μg/kg body weight or high dose 200 μg/kg body weight) leads to a dose-dependent attenuation of percent prepulse inhibition (PPI).|Products are for research use only. Not for human use.|
