Product Name :
SEL120-34A
Description:
SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
CAS:
1609522-33-9
Molecular Weight:
414.14
Formula:
C15H18Br2N4
Chemical Name:
6,7-dibromo-5-methyl-2-(piperazin-1-yl)-1,3-diazatricyclo[6.3.1.0⁴,¹²]dodeca-2,4,6,8(12)-tetraene
Smiles :
CC1=C2N=C(N3CCCC(=C32)C(Br)=C1Br)N1CCNCC1
InChiKey:
FSBMCTDYWXIBLM-UHFFFAOYSA-N
InChi :
InChI=1S/C15H18Br2N4/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4-18-5-8-20/h18H,2-8H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.|Product information|CAS Number: 1609522-33-9|Molecular Weight: 414.14|Formula: C15H18Br2N4|Chemical Name: 6,7-dibromo-5-methyl-2-(piperazin-1-yl)-1,3-diazatricyclo[6.3.1.0⁴,¹²]dodeca-2,4,6,8(12)-tetraene|Smiles: CC1=C2N=C(N3CCCC(=C32)C(Br)=C1Br)N1CCNCC1|InChiKey: FSBMCTDYWXIBLM-UHFFFAOYSA-N|InChi: InChI=1S/C15H18Br2N4/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4-18-5-8-20/h18H,2-8H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.ATP Assay Kit supplier |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SEL120-34A is a selective, ATP-competitive CDK8 inhibitor, with IC50 of 4.Trimetrexate Metabolic Enzyme/Protease 4 nM and 10.PMID:33349075 4 nM for CDK8/CycC and CDK19/CycC, respectively. SEL120-34A shows no obvious inhibition on CDK1, 2, 4, 6, 5, 7, and only weakly suppresses CDK9 (IC50, 1070 nM). SEL120-34A is active against a panel of AML cell lines (GI50In Vivo:|SEL120-34A (30, 60 mg/kg, p.o.) inhibits the growth of tumor in mice bearing MV4-11 cancer cells, and also arrests the growth of KG-1-derived tumors at 30 mg/kg via oral administration.|Products are for research use only. Not for human use.|
