Product Name :
XEN445
Description:
XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.
CAS:
1515856-92-4
Molecular Weight:
366.33
Formula:
C18H17F3N2O3
Chemical Name:
2-[(3S)-3-[(pyridin-2-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid
Smiles :
OC(=O)C1=CC(=CC=C1N1C[C@H](CC1)OCC1=CC=CC=N1)C(F)(F)F
InChiKey:
NBGRERFNOKZQLO-AWEZNQCLSA-N
InChi :
InChI=1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Dihydromyricetin Protocol
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.|Product information|CAS Number: 1515856-92-4|Molecular Weight: 366.33|Formula: C18H17F3N2O3|Synonym:|XEN 445|XEN-445|Chemical Name: 2-[(3S)-3-[(pyridin-2-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid|Smiles: OC(=O)C1=CC(=CC=C1N1C[C@H](CC1)OCC1=CC=CC=N1)C(F)(F)F|InChiKey: NBGRERFNOKZQLO-AWEZNQCLSA-N|InChi: InChI=1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Romosozumab Epigenetic Reader Domain |Shelf Life: ≥12 months if stored properly.PMID:33108584 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
