Product Name :
TIM-3 monoclonal antibody (1B10)
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Stable for at least 1 year after receipt when stored as recommended.
Description:
The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells. TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice. Blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth. Immunohistochemistry of TIM-3 in human colon carcinoma tissue with TIM-3 antibody at 5 µg/mL. Immunofluorescence of TIM-3 in transfected HEK293 cells with TIM-3 antibody at 10 µg/mL. Green: TIM-3 Antibody [1B10] Blue: DAPI staining Immunocytochemistry of TIM-3 in transfected HEK293 cells with TIM-3 antibody at 1 µg/mL. Lower left: Immunocytochemistry in transfected HEK293 cells with control mouse IgG antibody at 1 µg/mL. Flow cytometry analysis of TIM-3 overexpressing HEK293 cells using TIM-3 antibody and control mouse IgG antibody at 0.1 µg/ml. Blue: Untransfected HEK293 cells. Yellow: TIM-3 overexpressing HEK293 cells. Immunohistochemistry of TIM-3 in human colon carcinoma tissue with TIM-3 antibody at 5 µg/mL. Immunofluorescence of TIM-3 in transfected HEK293 cells with TIM-3 antibody at 10 µg/mL. Green: TIM-3 Antibody [1B10] Blue: DAPI staining Immunocytochemistry of TIM-3 in transfected HEK293 cells with TIM-3 antibody at 1 µg/mL.2443966-86-5 manufacturer Lower left: Immunocytochemistry in transfected HEK293 cells with control mouse IgG antibody at 1 µg/mL. Flow cytometry analysis of TIM-3 overexpressing HEK293 cells using TIM-3 antibody and control mouse IgG antibody at 0.1 µg/ml. Blue: Untransfected HEK293 cells.1383561-29-2 site Yellow: TIM-3 overexpressing HEK293 cells.PMID:29262086
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Additional Information :
| Alternative Name CD366, TIMD3 | Application Flow Cytometry, ICC, IF, IHC (PS), WB | Clone 1B10 | Formulation Liquid. In PBS containing 0.02% sodium azide and 50% glycerol. | Host Mouse | Immunogen Extracellular domain of human TIM-3. | Isotype IgG1κ | Species Reactivity Human | UniProt ID Q8TDQ0 | Unit of Measure (UM) µg
