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Plk1 monoclonal antibody (3F8)
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The polo-like kinases (PLKs) function in cell-cycle progression and in multiple stages of mitosis.{{1648843-04-2} site|{1648843-04-2} Biological Activity|{1648843-04-2} Description|{1648843-04-2} supplier} PLK1 is activated by phosphorylation of Thr210 at the G2/M phase boundary. Active PLK1 participates in mitotic entry through activation of Cdc25C and nuclear import of cyclin B1, thereby activating the Cdc2/cyclin B kinase. Western blot analysis of PLK1 mAb (3F8): Lane 1: MW marker, Lane 2: HeLa, Lane 3: Jurkat, Lane 4: PC-12, Lane 5: 3T3, Lane 6: HEK-293. Western blot analysis of PLK1 mAb (3F8): Lane 1: MW marker, Lane 2: HeLa, Lane 3: Jurkat, Lane 4: PC-12, Lane 5: 3T3, Lane 6: HEK-293.{{304896-28-4} MedChemExpress|{304896-28-4} Biological Activity|{304896-28-4} References|{304896-28-4} manufacturer}
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| Alternative Name Polo-like kinase 1 | Application WB | Application Notes Detects a band of ~62kDa by Western blot.PMID:29763148 | Clone 3F8 | Crossreactivity Weakly cross-reacts with mouse Plk1. | Formulation Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. | Host Mouse | Immunogen Recombinant fragment from the middle of human PLK1. | Isotype IgG1 | Recommendation Dilutions/Conditions Western Blot (1:1,000, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from hybridoma tissue culture supernatant. | Species Reactivity Human, Rat | UniProt ID P53350 | Unit of Measure (UM) µg
