Product Name :
Guanidinosuccinic acid
Description:
Guanidinosuccinic acid is a nitrogenous metabolite.
CAS:
6133-30-8
Molecular Weight:
175.14
Formula:
C5H9N3O4
Chemical Name:
(2S)-2-[(diaminomethylidene)amino]butanedioic acid
Smiles :
NC(N)=N[C@@H](CC(O)=O)C(O)=O
InChiKey:
VVHOUVWJCQOYGG-REOHCLBHSA-N
InChi :
InChI=1S/C5H9N3O4/c6-5(7)8-2(4(11)12)1-3(9)10/h2H,1H2,(H,9,10)(H,11,12)(H4,6,7,8)/t2-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Guanidinosuccinic acid is a nitrogenous metabolite.|Product information|CAS Number: 6133-30-8|Molecular Weight: 175.14|Formula: C5H9N3O4|Chemical Name: (2S)-2-[(diaminomethylidene)amino]butanedioic acid|Smiles: NC(N)=N[C@@H](CC(O)=O)C(O)=O|InChiKey: VVHOUVWJCQOYGG-REOHCLBHSA-N|InChi: InChI=1S/C5H9N3O4/c6-5(7)8-2(4(11)12)1-3(9)10/h2H,1H2,(H,9,10)(H,11,12)(H4,6,7,8)/t2-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 75 mg/mL (428.23 mM; Need ultrasonic). H2O : 6 mg/mL (34.26 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Iopamidol} MedChemExpress|{Iopamidol} {Biochemical Assay Reagents}|{Iopamidol} Purity & Documentation|{Iopamidol} In Vitro|{Iopamidol} supplier|{Iopamidol} Cancer} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Guanidinosuccinic acid, a constituent of normal urine, is elevated in the urine and serum of azotemic patients.{{Deoxycholic acid} web|{Deoxycholic acid} Metabolic Enzyme/Protease|{Deoxycholic acid} Biological Activity|{Deoxycholic acid} Data Sheet|{Deoxycholic acid} custom synthesis|{Deoxycholic acid} Epigenetic Reader Domain} Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, is administered by intraperitoneal (i.PMID:33272161 p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. Epileptogenic and toxic properties are assessed and Guanidinosuccinic acid brain levels following i.p. injection ae determined. In adult mice, Guanidinosuccinic acid induces long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD50 (and 95% confidence interval) of 363 (287-458) mg/kg (n=35), and an LD50 of 579 (445-756) mg/kg. The CD50 of Guanidinosuccinic acid corresponded with a brain concentration of 56 nmol/g tissue. Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions, When young mice are i.p. injected with a (for adults) subconvulsive dose of Guanidinosuccinic acid (250 mg/kg), an age-dependent decrease is noted in Guanidinosuccinic acid-induced convulsions and in the resulting brain concentration.|Products are for research use only. Not for human use.|
