Product Name :
MS402
Description:
MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice.
CAS:
1672684-68-2
Molecular Weight:
370.83
Formula:
C20H19ClN2O3
Chemical Name:
3-chloro-N-(4-methoxyphenyl)-4-[(2-methyl-3-oxocyclopent-1-en-1-yl)amino]benzamide
Smiles :
CC1C(=O)CCC=1NC1=CC=C(C=C1Cl)C(=O)NC1C=CC(=CC=1)OC
InChiKey:
VZTVTSICPINUNG-UHFFFAOYSA-N
InChi :
InChI=1S/C20H19ClN2O3/c1-12-17(9-10-19(12)24)23-18-8-3-13(11-16(18)21)20(25)22-14-4-6-15(26-2)7-5-14/h3-8,11,23H,9-10H2,1-2H3,(H,22,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Famotidine} MedChemExpress|{Famotidine} GPCR/G Protein|{Famotidine} Purity & Documentation|{Famotidine} In Vivo|{Famotidine} supplier|{Famotidine} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice.|Product information|CAS Number: 1672684-68-2|Molecular Weight: 370.{{Artemisinin} medchemexpress|{Artemisinin} Parasite|{Artemisinin} Biological Activity|{Artemisinin} In Vitro|{Artemisinin} custom synthesis|{Artemisinin} Autophagy} 83|Formula: C20H19ClN2O3|Chemical Name: 3-chloro-N-(4-methoxyphenyl)-4-[(2-methyl-3-oxocyclopent-1-en-1-yl)amino]benzamide|Smiles: CC1C(=O)CCC=1NC1=CC=C(C=C1Cl)C(=O)NC1C=CC(=CC=1)OC|InChiKey: VZTVTSICPINUNG-UHFFFAOYSA-N|InChi: InChI=1S/C20H19ClN2O3/c1-12-17(9-10-19(12)24)23-18-8-3-13(11-16(18)21)20(25)22-14-4-6-15(26-2)7-5-14/h3-8,11,23H,9-10H2,1-2H3,(H,22,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (269.PMID:31971723 67 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Reconstitution with naïve CD4+CD45RBhi cells isolated from spleen and lymph nodes of C57BL/6 mice, Rag1-/- mice begin losing weight after 4 week. MS402 (10 mg/kg; intraperitoneally twice a week for 3 weeks) shows much less weight loss.|Products are for research use only. Not for human use.|
