Product Name :
PC Methyltetrazine-PEG4-NHS carbonate ester
Description:
PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
CAS:
2055736-28-0
Molecular Weight:
785.75
Formula:
C35H43N7O14
Chemical Name:
2,5-dioxopyrrolidin-1-yl 1-{5-methoxy-4-[3-({2-[2-(2-{2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy}ethoxy)ethoxy]ethyl}carbamoyl)propoxy]-2-nitrophenyl}ethyl carbonate
Smiles :
CC1N=NC(=NN=1)C1C=CC(=CC=1)OCCOCCOCCOCCNC(=O)CCCOC1=CC(=C(C=C1OC)C(C)OC(=O)ON1C(=O)CCC1=O)[N+]([O-])=O
InChiKey:
FYXJZLYXHCHOII-UHFFFAOYSA-N
InChi :
InChI=1S/C35H43N7O14/c1-23(55-35(46)56-41-32(44)10-11-33(41)45)27-21-29(49-3)30(22-28(27)42(47)48)54-13-4-5-31(43)36-12-14-50-15-16-51-17-18-52-19-20-53-26-8-6-25(7-9-26)34-39-37-24(2)38-40-34/h6-9,21-23H,4-5,10-20H2,1-3H3,(H,36,43)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{PTP1B-IN-3} web|{PTP1B-IN-3} Metabolic Enzyme/Protease|{PTP1B-IN-3} Immunology/Inflammation|{PTP1B-IN-3} Technical Information|{PTP1B-IN-3} In Vivo|{PTP1B-IN-3} manufacturer}
Shelf Life:
≥12 months if stored properly.{{DOTMA} MedChemExpress|{DOTMA} Metabolic Enzyme/Protease|{DOTMA} Purity & Documentation|{DOTMA} Purity|{DOTMA} manufacturer|{DOTMA} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23819239
Additional information:
PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 2055736-28-0|Molecular Weight: 785.75|Formula: C35H43N7O14|Chemical Name: 2,5-dioxopyrrolidin-1-yl 1-{5-methoxy-4-[3-({2-[2-(2-{2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy}ethoxy)ethoxy]ethyl}carbamoyl)propoxy]-2-nitrophenyl}ethyl carbonate|Smiles: CC1N=NC(=NN=1)C1C=CC(=CC=1)OCCOCCOCCOCCNC(=O)CCCOC1=CC(=C(C=C1OC)C(C)OC(=O)ON1C(=O)CCC1=O)[N+]([O-])=O|InChiKey: FYXJZLYXHCHOII-UHFFFAOYSA-N|InChi: InChI=1S/C35H43N7O14/c1-23(55-35(46)56-41-32(44)10-11-33(41)45)27-21-29(49-3)30(22-28(27)42(47)48)54-13-4-5-31(43)36-12-14-50-15-16-51-17-18-52-19-20-53-26-8-6-25(7-9-26)34-39-37-24(2)38-40-34/h6-9,21-23H,4-5,10-20H2,1-3H3,(H,36,43)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|
