Product Name :
SIRT7 inhibitor 97491
Description:
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..
CAS:
1807758-81-1
Molecular Weight:
285.73
Formula:
C15H12ClN3O
Chemical Name:
N1-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]benzene-1,3-diamine
Smiles :
NC1=CC(=CC=C1)NC1=NC=C(O1)C1C=CC(Cl)=CC=1
InChiKey:
RMRVZWMKRCLSFX-UHFFFAOYSA-N
InChi :
InChI=1S/C15H12ClN3O/c16-11-6-4-10(5-7-11)14-9-18-15(20-14)19-13-3-1-2-12(17)8-13/h1-9H,17H2,(H,18,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Acyclovir} web|{Acyclovir} Apoptosis|{Acyclovir} Protocol|{Acyclovir} Data Sheet|{Acyclovir} supplier|{Acyclovir} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner.{{Streptavidin} MedChemExpress|{Streptavidin} {Biochemical Assay Reagents}|{Streptavidin} Protocol|{Streptavidin} In stock|{Streptavidin} custom synthesis|{Streptavidin} Autophagy} SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382.PMID:23789847 SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..|Product information|CAS Number: 1807758-81-1|Molecular Weight: 285.73|Formula: C15H12ClN3O|Chemical Name: N1-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]benzene-1,3-diamine|Smiles: NC1=CC(=CC=C1)NC1=NC=C(O1)C1C=CC(Cl)=CC=1|InChiKey: RMRVZWMKRCLSFX-UHFFFAOYSA-N|InChi: InChI=1S/C15H12ClN3O/c16-11-6-4-10(5-7-11)14-9-18-15(20-14)19-13-3-1-2-12(17)8-13/h1-9H,17H2,(H,18,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 500 mg/mL (1749.90 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells.|In Vivo:|SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice.|Products are for research use only. Not for human use.|
