Product Name :
Isoxanthopterin
Description:
Isoxanthopterin interferes with RNA and DNA synthesis. Isoxanthopterin, a natural intermediate in the pteridine pathway, plays critical roles in pigmentation and cell division. In vitro: Isoxanthopterin was identified as a pteridine of wide natural occurrence and was reported to exerts an inhibitory action on the synthesis of ribosomal RNA, possibly soluble RNA and on DNA in developing eggs of the milkweed bug Oncopeltus fasciatus. Such effects were measured by partially incubating dechorionated eggs in a solution containing isoxanthopterin and radioactive uridine or thymidine, and then testing the incorporation of the isotope into ribosomal RNA or DNA. The detailed mechanism of this inhibition had been discussed, and the tentative conclusion was agreed that it was due to an interaction between the pteridine and the nucleic acid (most probably DNA) . In vivo: Previous animal study showed that rats with inherited retinal dystrophy appeared to differ from healthy rats by an elevated isoxanthopterin excretion in urine. RCS rats responded to feeding of monapterin with an increase of isoxanthopterin excretion. This phenomenon supported the idea that the RCS rat had an increased xanthinoxidase activity compared with healthy rats . Clinical trial: So far, no clinical study has been conducted.
CAS:
529-69-1
Molecular Weight:
179.14
Formula:
C6H5N5O2
Chemical Name:
2-amino-1,4,7,8-tetrahydropteridine-4,7-dione
Smiles :
NC1NC2NC(=O)C=NC=2C(=O)N=1
InChiKey:
GLKCOBIIZKYKFN-UHFFFAOYSA-N
InChi :
InChI=1S/C6H5N5O2/c7-6-10-4-3(5(13)11-6)8-1-2(12)9-4/h1H,(H4,7,9,10,11,12,13)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Arbemnifosbuvir} web|{Arbemnifosbuvir} SARS-CoV|{Arbemnifosbuvir} Protocol|{Arbemnifosbuvir} Formula|{Arbemnifosbuvir} manufacturer|{Arbemnifosbuvir} Cancer}
Additional information:
Isoxanthopterin interferes with RNA and DNA synthesis.{{Palbociclib} MedChemExpress|{Palbociclib} Cell Cycle/DNA Damage|{Palbociclib} Technical Information|{Palbociclib} Formula|{Palbociclib} custom synthesis|{Palbociclib} Cancer} Isoxanthopterin, a natural intermediate in the pteridine pathway, plays critical roles in pigmentation and cell division.PMID:23075432 In vitro: Isoxanthopterin was identified as a pteridine of wide natural occurrence and was reported to exerts an inhibitory action on the synthesis of ribosomal RNA, possibly soluble RNA and on DNA in developing eggs of the milkweed bug Oncopeltus fasciatus. Such effects were measured by partially incubating dechorionated eggs in a solution containing isoxanthopterin and radioactive uridine or thymidine, and then testing the incorporation of the isotope into ribosomal RNA or DNA. The detailed mechanism of this inhibition had been discussed, and the tentative conclusion was agreed that it was due to an interaction between the pteridine and the nucleic acid (most probably DNA) . In vivo: Previous animal study showed that rats with inherited retinal dystrophy appeared to differ from healthy rats by an elevated isoxanthopterin excretion in urine. RCS rats responded to feeding of monapterin with an increase of isoxanthopterin excretion. This phenomenon supported the idea that the RCS rat had an increased xanthinoxidase activity compared with healthy rats . Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 529-69-1|Molecular Weight: 179.14|Formula: C6H5N5O2|Chemical Name: 2-amino-1,4,7,8-tetrahydropteridine-4,7-dione|Smiles: NC1NC2NC(=O)C=NC=2C(=O)N=1|InChiKey: GLKCOBIIZKYKFN-UHFFFAOYSA-N|InChi: InChI=1S/C6H5N5O2/c7-6-10-4-3(5(13)11-6)8-1-2(12)9-4/h1H,(H4,7,9,10,11,12,13)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
