Product Name :
Murizatoclax
Description:
Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer.
CAS:
2245848-05-7
Molecular Weight:
765.44
Formula:
C42H57ClN4O5S
Chemical Name:
(1S,3’R,6’R,7’R,11’S,12’R)-7′-{[(9aR)-octahydro-1H-pyrido[1,2-a]pyrazin-2-yl]methyl}-6-chloro-7′-methoxy-11′,12′-dimethyl-3,4-dihydro-2H-20′-oxa-13’λ⁶-thia-1′,14′-diazaspiro[naphthalene-1,22′-tetracyclo[14.7.2.0³,⁶.0¹⁹,²⁴]pentacosane]-8′,16′(25′),17′,19′(24′)-tetraene-13′,13′,15′-trione
Smiles :
CO[C@]1(CN2C[C@H]3CCCCN3CC2)C=CC[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(C=C2)OC[C@@]2(CN3C[C@@H]3CC[C@@H]13)CCCC1=CC(Cl)=CC=C21 |t:16|
InChiKey:
BJTFTQIBRVBSBH-PKUKKRJXSA-N
InChi :
InChI=1S/C42H57ClN4O5S/c1-29-8-6-18-42(51-3,27-45-20-21-46-19-5-4-10-35(46)25-45)37-14-11-33(37)24-47-26-41(17-7-9-31-22-34(43)13-15-36(31)41)28-52-39-16-12-32(23-38(39)47)40(48)44-53(49,50)30(29)2/h6,12-13,15-16,18,22-23,29-30,33,35,37H,4-5,7-11,14,17,19-21,24-28H2,1-3H3,(H,44,48)/b18-6-/t29-,30+,33-,35+,37+,41-,42-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer.|Product information|CAS Number: 2245848-05-7|Molecular Weight: 765.44|Formula: C42H57ClN4O5S|Chemical Name: (1S,3’R,6’R,7’R,11’S,12’R)-7′-{[(9aR)-octahydro-1H-pyrido[1,2-a]pyrazin-2-yl]methyl}-6-chloro-7′-methoxy-11′,12′-dimethyl-3,4-dihydro-2H-20′-oxa-13’λ⁶-thia-1′,14′-diazaspiro[naphthalene-1,22′-tetracyclo[14.7.2.0³,⁶.0¹⁹,²⁴]pentacosane]-8′,16′(25′),17′,19′(24′)-tetraene-13′,13′,15′-trione|Smiles: CO[C@]1(CN2C[C@H]3CCCCN3CC2)C=CC[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(C=C2)OC[C@@]2(CN3C[C@@H]3CC[C@@H]13)CCCC1=CC(Cl)=CC=C21 |t:16||InChiKey: BJTFTQIBRVBSBH-PKUKKRJXSA-N|InChi: InChI=1S/C42H57ClN4O5S/c1-29-8-6-18-42(51-3,27-45-20-21-46-19-5-4-10-35(46)25-45)37-14-11-33(37)24-47-26-41(17-7-9-31-22-34(43)13-15-36(31)41)28-52-39-16-12-32(23-38(39)47)40(48)44-53(49,50)30(29)2/h6,12-13,15-16,18,22-23,29-30,33,35,37H,4-5,7-11,14,17,19-21,24-28H2,1-3H3,(H,44,48)/b18-6-/t29-,30+,33-,35+,37+,41-,42-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lumateperone} site|{Lumateperone} 5-HT Receptor|{Lumateperone} Biological Activity|{Lumateperone} Data Sheet|{Lumateperone} custom synthesis|{Lumateperone} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Girentuximab} web|{Girentuximab} Carbonic Anhydrase|{Girentuximab} Biological Activity|{Girentuximab} In Vivo|{Girentuximab} manufacturer|{Girentuximab} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24605203 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AMG 397 potently disrupts the interaction between MCL1 and BIM in OPM2 cells, induces clear increases in Caspase-3/7 activity within one hour.|In Vivo:|Murizatoclax (25-50 mg/kg; p.o. once or twice weekly) exhibits significant tumor regressions in mice bearing OPM2 xenografts. Murizatoclax (10-60 mg/kg; p.o. twice weekly) achieves 47% MOLM-13 orthotopic tumor growth inhibition (TGI), 99% TGI and 75% regression at the dose of 10, 30 and 60 mg/kg, respectively.|Products are for research use only. Not for human use.|
