Product Name :
HLI 373 dihydrochloride
Description:
HLI-373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53. HLI-373 induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.
CAS:
1782531-99-0
Molecular Weight:
414.33
Formula:
C18H25Cl2N5O2
Chemical Name:
5-((3-(dimethylamino)propyl)amino)-3, 10-dimethylpyrimido[4, 5-b]quinoline-2, 4(3H, 10H)-dione dihydrochloride
Smiles :
Cl.Cl.CN(C)CCCNC1=C2C(=NC(=O)N(C)C2=O)N(C)C2=CC=CC=C21
InChiKey:
WUEMKAQTAIRDOA-UHFFFAOYSA-N
InChi :
InChI=1S/C18H23N5O2.2ClH/c1-21(2)11-7-10-19-15-12-8-5-6-9-13(12)22(3)16-14(15)17(24)23(4)18(25)20-16;;/h5-6,8-9,19H,7,10-11H2,1-4H3;2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Methoxsalen} site|{Methoxsalen} Cytochrome P450|{Methoxsalen} Biological Activity|{Methoxsalen} In Vivo|{Methoxsalen} supplier|{Methoxsalen} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
HLI-373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53. HLI-373 induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.{{Emapalumab} medchemexpress|{Emapalumab} IFNAR|{Emapalumab} Protocol|{Emapalumab} Description|{Emapalumab} custom synthesis|{Emapalumab} Autophagy} |Product information|CAS Number: 1782531-99-0|Molecular Weight: 414.PMID:24179643 33|Formula: C18H25Cl2N5O2|Chemical Name: 5-((3-(dimethylamino)propyl)amino)-3, 10-dimethylpyrimido[4, 5-b]quinoline-2, 4(3H, 10H)-dione dihydrochloride|Smiles: Cl.Cl.CN(C)CCCNC1=C2C(=NC(=O)N(C)C2=O)N(C)C2=CC=CC=C21|InChiKey: WUEMKAQTAIRDOA-UHFFFAOYSA-N|InChi: InChI=1S/C18H23N5O2.2ClH/c1-21(2)11-7-10-19-15-12-8-5-6-9-13(12)22(3)16-14(15)17(24)23(4)18(25)20-16;;/h5-6,8-9,19H,7,10-11H2,1-4H3;2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Jirouta Kitagaki, et al. Targeting Tumor Cells Expressing p53 With a Water-Soluble Inhibitor of Hdm2. Mol Cancer Ther. 2008 Aug;7(8):2445-54.Jagrati Jain, et al. Inhibitors of Ubiquitin E3 Ligase as Potential New Antimalarial Drug Leads. BMC Pharmacol Toxicol. 2017 Jun 2;18(1):40.Ying Chen, et al. MDM2 Promotes Epithelial-Mesenchymal Transition and Metastasis of Ovarian Cancer SKOV3 Cells. Br J Cancer. 2017 Oct 10;117(8):1192-1201.Products are for research use only. Not for human use.|
