Product Name :
Substance P TFA
Description:
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
CAS:
148470-19-3
Molecular Weight:
1461.65
Formula:
C65H99F3N18O15S
Chemical Name:
(S)-N1-((5S, 8S, 14S, 17S, 20S)-23-amino-14, 17-dibenzyl-5-carbamoyl-8-isobutyl-7, 10, 13, 16, 19, 23-hexaoxo-2-thia-6, 9, 12, 15, 18-pentaazatricosan-20-yl)-2-((S)-1-((S)-6-amino-2-((S)-1-((S)-2-amino-5-(diaminomethyleneamino)pentanoyl)pyrrolidine-2-carboxamido)hexanoyl)pyrrolidine-2-carboxamido)pentanediamide 2, 2, 2-trifluoroacetate
Smiles :
CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCSC)C(N)=O.OC(=O)C(F)(F)F
InChiKey:
HJUBUMANGKVTGH-HDKZLILXSA-N
InChi :
InChI=1S/C63H98N18O13S.C2HF3O2/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;3-2(4,5)1(6)7/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);(H,6,7)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).|Product information|CAS Number: 148470-19-3|Molecular Weight: 1461.65|Formula: C65H99F3N18O15S|Chemical Name: (S)-N1-((5S, 8S, 14S, 17S, 20S)-23-amino-14, 17-dibenzyl-5-carbamoyl-8-isobutyl-7, 10, 13, 16, 19, 23-hexaoxo-2-thia-6, 9, 12, 15, 18-pentaazatricosan-20-yl)-2-((S)-1-((S)-6-amino-2-((S)-1-((S)-2-amino-5-(diaminomethyleneamino)pentanoyl)pyrrolidine-2-carboxamido)hexanoyl)pyrrolidine-2-carboxamido)pentanediamide 2, 2, 2-trifluoroacetate|Smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCSC)C(N)=O.OC(=O)C(F)(F)F|InChiKey: HJUBUMANGKVTGH-HDKZLILXSA-N|InChi: InChI=1S/C63H98N18O13S.C2HF3O2/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;3-2(4,5)1(6)7/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);(H,6,7)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-;/m0.{{Caspofungin} MedChemExpress|{Caspofungin} Bacterial|{Caspofungin} Purity & Documentation|{Caspofungin} Description|{Caspofungin} custom synthesis|{Caspofungin} Epigenetic Reader Domain} /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 100 mg/mL (68.{{Efalizumab} MedChemExpress|{Efalizumab} Cytoskeleton|{Efalizumab} Purity & Documentation|{Efalizumab} Description|{Efalizumab} custom synthesis|{Efalizumab} Cancer} 41 mM; Need ultrasonic).PMID:23865629 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.|Products are for research use only. Not for human use.|
