Product Name :
Tasisulam sodium
Description:
Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization.
CAS:
519055-63-1
Molecular Weight:
437.09
Formula:
C11H5BrCl2NNaO3S2
Chemical Name:
N-[(5-bromothiophen-2-yl)sulfonyl]-2,4-dichloro-N-sodiobenzamide
Smiles :
O=C(C1=CC=C(Cl)C=C1Cl)N([Na])S(=O)(=O)C1=CC=C(Br)S1
InChiKey:
JCOHXVDKRMWUQP-UHFFFAOYSA-M
InChi :
InChI=1S/C11H6BrCl2NO3S2.Na/c12-9-3-4-10(19-9)20(17,18)15-11(16)7-2-1-6(13)5-8(7)14;/h1-5H,(H,15,16);/q;+1/p-1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death.{{Tefibazumab} medchemexpress|{Tefibazumab} Technical Information|{Tefibazumab} Data Sheet|{Tefibazumab} supplier|{Tefibazumab} Epigenetic Reader Domain} Tasisulam inhibits mitotic progression and induces vascular normalization.{{Bavituximab} web|{Bavituximab} Purity & Documentation|{Bavituximab} Formula|{Bavituximab} manufacturer|{Bavituximab} Epigenetics} |Product information|CAS Number: 519055-63-1|Molecular Weight: 437.PMID:23319057 09|Formula: C11H5BrCl2NNaO3S2|Chemical Name: N-[(5-bromothiophen-2-yl)sulfonyl]-2,4-dichloro-N-sodiobenzamide|Smiles: O=C(C1=CC=C(Cl)C=C1Cl)N([Na])S(=O)(=O)C1=CC=C(Br)S1|InChiKey: JCOHXVDKRMWUQP-UHFFFAOYSA-M|InChi: InChI=1S/C11H6BrCl2NO3S2.Na/c12-9-3-4-10(19-9)20(17,18)15-11(16)7-2-1-6(13)5-8(7)14;/h1-5H,(H,15,16);/q;+1/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Tasisulam sodium (200 nM-200 μM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s of 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively. Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation. Tasisulam sodium (200 nM-200 μM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models. Tasisulam sodium also blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation.|Products are for research use only. Not for human use.|
