Product Name :
TPOP146
Description:
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4.
CAS:
2018300-62-2
Molecular Weight:
481.58
Formula:
C27H35N3O5
Chemical Name:
7-(3,5-dimethoxyphenyl)-N-[(3S)-1-methylpiperidin-3-yl]-4-propanoyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide
Smiles :
CN1CCC[C@@H](C1)NC(=O)C1C=C(C=C2CN(CCOC2=1)C(=O)CC)C1C=C(C=C(C=1)OC)OC
InChiKey:
CUJLWYCUPPPASA-NRFANRHFSA-N
InChi :
InChI=1S/C27H35N3O5/c1-5-25(31)30-9-10-35-26-20(16-30)11-18(19-12-22(33-3)15-23(13-19)34-4)14-24(26)27(32)28-21-7-6-8-29(2)17-21/h11-15,21H,5-10,16-17H2,1-4H3,(H,28,32)/t21-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4.|Product information|CAS Number: 2018300-62-2|Molecular Weight: 481.58|Formula: C27H35N3O5|Chemical Name: 7-(3,5-dimethoxyphenyl)-N-[(3S)-1-methylpiperidin-3-yl]-4-propanoyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide|Smiles: CN1CCC[C@@H](C1)NC(=O)C1C=C(C=C2CN(CCOC2=1)C(=O)CC)C1C=C(C=C(C=1)OC)OC|InChiKey: CUJLWYCUPPPASA-NRFANRHFSA-N|InChi: InChI=1S/C27H35N3O5/c1-5-25(31)30-9-10-35-26-20(16-30)11-18(19-12-22(33-3)15-23(13-19)34-4)14-24(26)27(32)28-21-7-6-8-29(2)17-21/h11-15,21H,5-10,16-17H2,1-4H3,(H,28,32)/t21-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (207.{{Tarextumab} MedChemExpress|{Tarextumab} Neuronal Signaling|{Tarextumab} Technical Information|{Tarextumab} Formula|{Tarextumab} custom synthesis|{Tarextumab} Cancer} 65 mM).{{Oxaliplatin} MedChemExpress|{Oxaliplatin} Apoptosis|{Oxaliplatin} Biological Activity|{Oxaliplatin} Description|{Oxaliplatin} custom synthesis|{Oxaliplatin} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23983589 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Exposure to 1 μM TPOP146 results in a significant decrease of recovery half-life that is comparable to the construct that contained the bromodomain inactivating mutation N1168F, demonstrating that TPOP146 targets the CBP bromodomain in the nucleus and is capable of competing with acetyl-lysine mediated interactions of the CBP bromodomain in cellular environments.|References:|Popp TA, et al. Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors. J Med Chem. 2016 Oct 13;59(19):8889-8912.Products are for research use only. Not for human use.|
