Product Name :
MMV666810
Description:
MMV666810 is a novel inhibitor of Plasmodium falciparum gametocytes. MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).
CAS:
1450666-97-3
Molecular Weight:
442.43
Formula:
C23H21F3N4O2
Chemical Name:
1-(4-{5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}benzoyl)piperidin-4-ol
Smiles :
NC1=NC=C(N=C1C1C=CC(=CC=1)C(F)(F)F)C1C=CC(=CC=1)C(=O)N1CCC(O)CC1
InChiKey:
FKDIWALLMXDOBS-UHFFFAOYSA-N
InChi :
InChI=1S/C23H21F3N4O2/c24-23(25,26)17-7-5-15(6-8-17)20-21(27)28-13-19(29-20)14-1-3-16(4-2-14)22(32)30-11-9-18(31)10-12-30/h1-8,13,18,31H,9-12H2,(H2,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MMV666810 is a novel inhibitor of Plasmodium falciparum gametocytes. MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).|Product information|CAS Number: 1450666-97-3|Molecular Weight: 442.43|Formula: C23H21F3N4O2|Chemical Name: 1-(4-{5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}benzoyl)piperidin-4-ol|Smiles: NC1=NC=C(N=C1C1C=CC(=CC=1)C(F)(F)F)C1C=CC(=CC=1)C(=O)N1CCC(O)CC1|InChiKey: FKDIWALLMXDOBS-UHFFFAOYSA-N|InChi: InChI=1S/C23H21F3N4O2/c24-23(25,26)17-7-5-15(6-8-17)20-21(27)28-13-19(29-20)14-1-3-16(4-2-14)22(32)30-11-9-18(31)10-12-30/h1-8,13,18,31H,9-12H2,(H2,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Abraxane} MedChemExpress|{Abraxane} Autophagy|{Abraxane} Biological Activity|{Abraxane} References|{Abraxane} supplier|{Abraxane} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{TCEP} medchemexpress|{TCEP} Technical Information|{TCEP} References|{TCEP} supplier|{TCEP} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25804060 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7(10):2904-2916. Products are for research use only. Not for human use.|
