Product Name :
XPC-6444
Description:
XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity.
CAS:
2230144-21-3
Molecular Weight:
498.58
Formula:
C22H25F3N4O2S2
Chemical Name:
4-{[(2-{[tert-butyl(methyl)amino]methyl}-6-fluorophenyl)methyl]amino}-2,6-difluoro-N-(1,3-thiazol-4-yl)benzene-1-sulfonamide
Smiles :
CN(CC1=CC=CC(F)=C1CNC1=CC(F)=C(C(F)=C1)S(=O)(=O)NC1=CSC=N1)C(C)(C)C
InChiKey:
VOJFVKGTRNXOTJ-UHFFFAOYSA-N
InChi :
InChI=1S/C22H25F3N4O2S2/c1-22(2,3)29(4)11-14-6-5-7-17(23)16(14)10-26-15-8-18(24)21(19(25)9-15)33(30,31)28-20-12-32-13-27-20/h5-9,12-13,26,28H,10-11H2,1-4H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Cefiderocol} MedChemExpress|{Cefiderocol} Antibiotic|{Cefiderocol} Purity & Documentation|{Cefiderocol} Description|{Cefiderocol} supplier|{Cefiderocol} Autophagy}
Additional information:
XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6). XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM). XPC-6444 shows anticonvulsant activity.|Product information|CAS Number: 2230144-21-3|Molecular Weight: 498.{{Sildenafil} medchemexpress|{Sildenafil} Autophagy|{Sildenafil} Biological Activity|{Sildenafil} Purity|{Sildenafil} manufacturer|{Sildenafil} Cancer} 58|Formula: C22H25F3N4O2S2|Chemical Name: 4-{[(2-{[tert-butyl(methyl)amino]methyl}-6-fluorophenyl)methyl]amino}-2,6-difluoro-N-(1,3-thiazol-4-yl)benzene-1-sulfonamide|Smiles: CN(CC1=CC=CC(F)=C1CNC1=CC(F)=C(C(F)=C1)S(=O)(=O)NC1=CSC=N1)C(C)(C)C|InChiKey: VOJFVKGTRNXOTJ-UHFFFAOYSA-N|InChi: InChI=1S/C22H25F3N4O2S2/c1-22(2,3)29(4)11-14-6-5-7-17(23)16(14)10-26-15-8-18(24)21(19(25)9-15)33(30,31)28-20-12-32-13-27-20/h5-9,12-13,26,28H,10-11H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23381601 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|XPC-6444 shows high selectivity over NaV1.1 and NaV1.5.|In Vivo:|XPC-6444 exhibits good metabolic stability in human liver microsomes and hepatocytes, and low potential for MDR1 mediated efflux.|Products are for research use only. Not for human use.|
