Leuk. Res. 2003, 27, 794. 58. Murphy, J.R.; Bishai, W.; Borowski, M.; Miyanohara, A.; Boyd, J.; Nagle, S. Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocytestimulating hormone fusion protein. Proc. Natl. Acad. Sci. USA 1986, 83, 8258262. 59. Kreitman, R.J. Immunotoxins for targeted cancer therapy. Aaps J. 2006, 8, E532 551. 60. Hogge, D.E.; Yalcintepe, L.; Wong, S.H.; Gerhard, B.; Frankel, A.E. Variant diphtheria toxin-interleukin-3 fusion proteins with improved receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors. Clin. Cancer Res. 2006, 12, 1284291. 61. Hall, P.D.; Willingham, M.C.; Kreitman, R.J.; Frankel, A.E. Dt388-gm-csf, a novel fusion toxin consisting of a truncated diphtheria toxin fused to human granulocyte-macrophage colony-stimulating element, prolongs host survival within a scid mouse model of acute myeloid leukemia. Leukemia 1999, 13, 62933. 62. Feuring-Buske, M.; Frankel, A.; Gerhard, B.; Hogge, D. Variable cytotoxicity of diphtheria toxin 388-granulocyte-macrophage colony-stimulating issue fusion protein for acute myelogenous leukemia stem cells. Exp. Hematol. 2000, 28, 1390400. 63. Duvic, M.; Talpur, R. Optimizing denileukin diftitox (ontak) therapy.Lipopolysaccharides Future Oncol.Asiatic acid 2008, four, 45769.PMID:24282960 64. Cohen, K.A.; Liu, T.F.; Cline, J.M.; Wagner, J.D.; Hall, P.D.; Frankel, A.E. Toxicology and pharmacokinetics of dt388il3, a fusion toxin consisting of a truncated diphtheria toxin (dt388) linked to human interleukin three (il3), in cynomolgus monkeys. Leuk. Lymphoma 2004, 45, 1647656.Toxins 2013,65. Black, J.H.; McCubrey, J.A.; Willingham, M.C.; Ramage, J.; Hogge, D.E.; Frankel, A.E. Diphtheria toxin-interleukin-3 fusion protein (dt(388)il3) prolongs disease-free survival of leukemic immunocompromised mice. Leukemia 2003, 17, 15559. 66. Reshetnyak, Y.K.; Andreev, O.A.; Lehnert, U.; Engelman, D.M. Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc. Natl. Acad. Sci. USA 2006, 103, 6460465. 67. Reshetnyak, Y.K.; Segala, M.; Andreev, O.A.; Engelman, D.M. A monomeric membrane peptide that lives in three worlds: In resolution, attached to, and inserted across lipid bilayers. Biophys. J. 2007, 93, 2363372. 68. Antignani, A.; Youle, R.J. How do Bax and Bak result in permeabilization in the outer mitochondrial membrane Curr. Opin. Cell Biol. 2006, 18, 68589. 69. Youle, R.J.; Strasser, A. The Bcl-2 protein family members: Opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9, 479. 70. Minn, A.J.; Velez, P.; Schendel, S.L.; Liang, H.; Muchmore, S.W.; Fesik, S.W.; Fill, M.; Thompson, C.B. Bcl-X(L) forms an ion channel in synthetic lipid membranes. Nature 1997, 385, 35357. 71. Hsu, Y.T.; Wolter, K.G.; Youle, R.J. Cytosol-to-membrane redistribution of bax and Bcl-X(L) through apoptosis. Proc. Natl. Acad. Sci. USA 1997, 94, 3668672. 2013 by the authors; licensee MDPI, Basel, Switzerland. This short article is definitely an open access article distributed beneath the terms and situations on the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Short article pubs.acs.org/BiomacSynthesis and Characterization of Injectable, Biodegradable, Phosphate-Containing, Chemically Cross-Linkable, Thermoresponsive Macromers for Bone Tissue EngineeringBrendan M. Watson, F. Kurtis Kasper, Paul S. Engel, and Antonios G. Mikos*,Department of Bioengineering, Rice University 6500 Principal Street, Houston, Texas 77030, United.
