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Nter, Tehran University of Medical Sciences, Tehran, Iran. 3 XRD Analysis Laboratory, College of Sciences, Tehran University, Tehran, Iran. Received: 20 February 2014 Accepted: 30 May well 2014 Published: 11 June 2014 References 1. Courrier H, Butz N, Vandamme TF: Pulmonary drug delivery systems: recent developments and prospects. Crit Rev Ther Drug Carrier Syst 2002, 19:no. four o. 5. two. Groneberg D, Witt C, Wagner U, Chung K, Fischer A: Fundamentals of pulmonary drug delivery. Resp Med 2003, 97:38287. 3. Labiris N, Dolovich M: Pulmonary drug delivery. Component I: physiological elements affecting therapeutic effectiveness of aerosolized drugs. Brit J Clin Pharmacol 2003, 56:58899. four. Zeng XM, Martin GP, Marriott C: The controlled delivery of drugs towards the lung. Int J Pharm 1995, 124:14964. five. Hardy JG, Chadwick TS: Sustained release drug delivery for the lungs. Clin Pharmacokin 2000, 39:1. six. Cook RO, Pannu RK, Kellaway IW: Novel sustained release microspheres for pulmonary drug delivery. J Handle Rel 2005, 104:790. 7. Schreier H, Gonzalez-Rothi RJ, Stecenko AA: Pulmonary delivery of liposomes. J Control Rel 1993, 24:20923. 8. Lu D, Hickey AJ: Liposomal dry powders as aerosols for pulmonary delivery of proteins. AAPS PharmSciTech 2005, six:E641 648. 9. Abra R, Mihalko PJ, Schreier H: The effect of lipid composition upon the encapsulation and in vitro leakage of metaproterenol sulfate from 0.2 m diameter, extruded, multilamellar liposomes. J Handle Rel 1990, 14:718.ten. Parthasarathy R, Gilbert B, Mehta K: Aerosol delivery of liposomal all-transretinoic acid to the lungs. Cancer Chemother Pharmacol 1999, 43:27783. 11. Pilcer G, Amighi K: Formulation tactic and use of excipients in pulmonary drug delivery. Int J Pharm 2010, 392:19. 12. Taylor KM, Fan SJ: Liposomes for drug delivery for the respiratory tract. Drug Dev Ind Pharm 1993, 19:12342. 13. Kellaway IW, Farr SJ: Liposomes as drug delivery systems towards the lung. Adv Drug Deliv Rev 1990, five:14961. 14. Niven RW, Schreier H: Nebulization of liposomes. I. Effects of lipid composition. Pharm Res 1990, 7:1127133. 15. Desai TR, Hancock RE, Finlay WH: Delivery of liposomes in dry powder form: aerodynamic dispersion properties. Eur J Pharm Sci 2003, 20:45967. 16. Jaspart S, Bertholet P, Piel G, DognJ-M, Delattre L, Evrard B: Strong lipid microparticles as a sustained release system for pulmonary drug delivery. Eur J Pharm Biopharm 2007, 65:476. 17. Sebti T, Amighi K: Preparation and in vitro evaluation of lipidic carriers and fillers for inhalation. Eur J of Pharm Biopharm 2006, 63:518. 18. M ler RH, M er K, Gohla S: Solid lipid nanoparticles (SLN) for controlled drug delivery critique on the state in the art. Eur J Pharm Biopharm 2000, 50:16177. 19.Vatiquinone Trotta M, Cavalli R, Carlotti M, Battaglia L, Debernardi F: Strong lipid microparticles carrying insulin formed by solvent-in-water emulsion iffusion strategy.Tetracycline Int J Pharm 2005, 288:28188.PMID:24578169 20. Pilcer G, Sebti T, Amighi K: Formulation and characterization of lipidcoated tobramycin particles for dry powder inhalation. Pharm Res 2006, 23:93140. 21. Masters K: Spray drying handbook. 5th edition. New York: Longman; 1991. 22. Steckel H, Brandes HG: A novel spray-drying strategy to generate low density particles for pulmonary delivery. Int J Pharm 2004, 278:18795. 23. Chow AH, Tong HH, Chattopadhyay P, Shekunov BY: Particle engineering for pulmonary drug delivery. Pharm Res 2007, 24:41137. 24. Son Y-J, McConville JT: Advancements in dry powder delivery to the lung. D.

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