nds with a superior antioxidant capacity, that is directly related to the phytochemical content material. A. hierochuntica (HSV-1 Source particularly aqueous extract) protects rats against CCl4 -induced oxidative pressure and acute kidney injury, as evidenced by a considerable drop in MDA levels and elevated GSH and SOD activity, as well because the cessation of biochemical and histological alterations within the kidneys. The protective efficacy may arise from the antioxidant and cost-free radical scavenging properties from the phenolic compounds present in the A. hierochuntica extracts. These characteristics help to clarify the plant’s medicinal efficacy as a herbal medication. Additional Mcl-1 review research is required to absolutely describe the active principles inside a. hierochuntica, and this study is meant to stimulate extra comprehensive associated study to provide sufficient information and recommendations for defining its mechanisms and protected doses.Author Contributions: Conceptualization, T.I.A., Y.M.A. and H.B.; methodology, investigation, H.B. and H.A.A.-R.; information curation, T.I.A. and Y.M.A.; writing–original draft preparation, overview,Nutrients 2021, 13,13 ofand editing; H.B. and H.A.A.-R. All authors have study and agreed for the published version of the manuscript. Funding: The researchers would like to thank the Deanship of Scientific Study, Qassim University, for funding the publication of this project. Institutional Critique Board Statement: Not applicable. Informed Consent Statement: Not applicable. Information Availability Statement: The data presented in this study are available on request in the corresponding author. Conflicts of Interest: The authors declare no conflict of interest.AbbreviationsABTS: two,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid); AOA: antioxidant activity; BHA: butylated hydroxyanisole; BHA: butylated hydroxyanisole; DPPH: 1,1-diphenyl-2-picryl hydrazine; dw: dry weight; GA: gallic acid; GAE: gallic acid equivalent; GSH: reduced-glutathione; HPLC-DAD: high-performance liquid chromatography diode array detection; KAE: A. hierochuntica aqueous extract; KEE: A. hierochuntica ethanolic extract; MDA: malonaldehyde; QE: quercetin equivalent; RAA: relative antioxidant activity; ROS: reactive oxygen species; RSA: radical scavenging activity; Se: selenium; SE: common error; SOD: superoxide dismutase; TC: total carotenoids; TC: total carotenoids; TF: total flavonoids; TE: trolox equivalents; TFL: total flavonols; TPC: total phenolic compounds.
Received: 25 October 2021 Accepted: 15 November 2021 Published: 17 NovemberPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This short article is an open access post distributed under the terms and circumstances on the Inventive Commons Attribution (CC BY) license ( creativecommons.org/licenses/by/ four.0/).Cancer can be a top trigger of death worldwide, accounting for almost ten million deaths in 2020. Among the techniques that have been created to treat cancer, chemotherapy is utilised mainly to treat metastatic cancer that can’t be eradicated with surgery or radiotherapy. Though chemotherapy is the most productive system to eradicate cancer, it entails quite a few challenges for instance evolution of multidrug resistance (MDR) in cancer cells, which contains altered drug activation resulting from metabolism and excretion, and enhanced repair of DNA harm brought on by anti-cancer drugs. The main mechanism underlying MDR is
