B ahead of print] three. Bottiroli S, Viana M, Sances G, et al. Psychological aspects connected to failure of detoxification therapy in chronic headache associated with medication overuse. Cephalalgia 2016; 36: 1356-1365. four. Tassorelli C, Jensen R, Allena M, De Icco R, Sances G, Katsarava Z, Lainez M, Leston J, Fadic R, Spadafora S, Pagani M, Nappi G; the COMOESTAS Consortium. A consensus protocol for the management of medicationoveruse headache: Evaluation within a multicentric, multinational study. Cephalalgia. 2014 Aug; 34(9):645-655.S57 Chronic Headaches Cefalee Croniche Grazia Sances1, Sara Bottiroli1, Michele Viana1, Natascia Ghiotto1, Elena Guaschino1, Marta Allena1, Cristina Tassorelli1-2 1 Headache Science Center (HSC), C. Mondino National Institute of Neurology Foundation, Pavia, Italy; 2Dept of Brain and Behavioural Sciences, University of Pavia, Italy Correspondence: Grazia Sances ([email protected]) The Journal of Headache and Pain 2017, 18(Suppl 1):S57 Chronic headaches are a relevant overall health trouble characterized by significant disability, poor quality of life and higher economic burden (1). Essentially the most widespread forms consist of chronic migraine (CM) and medication overuse headache (MOH), which are frequently related, provided that the majority of CM sufferers do overuse acute medicines (CM with MO). Chronic headaches represent a challenge for physicians, provided their frequent resistance to therapies, risk of relapse and linked comorbidities. Their management includes quite a few actions aimed to: 1) make a right diagnosis excluding secondary forms; 2) identify exacerbating aspects; 3) treat comorbidities; four) recognize and address medication overuse; 5) establish a therapeutic agreement with patient; 6) define an integrated care approach. Patienthistory collection is vital for defining headache onset and its lifelong course, chronicization things, and outcomes of preceding therapies (acute and prophylactic). Overused drug discontinuation may be the very first approach for MOH and it can be accomplished through a number of modalities – in-patient or out-patient withdrawal procedures, advice alone depending on several headache-associated or patient-associated factors. During withdrawal, sufficient care is expected to help the patient to go through the remedy phases, provided the frequent occurrence of headache recrudescence. Headache diaries represent useful tools in monitoring attacks frequency, detecting medication overuse, checking therapies outcomes, and assessing disability improvements. A relevant problem in MOH is the threat of relapse into overuse right after thriving withdrawal. You can find only couple of controlled pharmacological trials on the management of MO in CM, which will not permit to derive precise figures on the threat of relapse into MO associated to certain therapies. Furthermore, theS58 Headache in the elderly Carlo Lisotto Headache Centre, Division of Neurology, Azienda Sanitaria Friuli Occidentale, Pordenone, Italy The Journal of Headache and Discomfort 2017, 18(Suppl 1):S58 Background Headache prevalence is age-dependent and decreases progressively over time, specifically beginning from the age of 55-60. The incidence of principal headaches declines, whereas secondary headaches have a tendency to take place more often with increasing age [1]. Although the prevalence of headache inside the elderly is relevant, few studies have already been performed in individuals more than 65 so far. Supplies and Solutions The clinical records of 9075 consecutive Difloxacin In Vivo outpatients aged over 18 referred to.