Ce of any proof of plaque rupture, OCTerosion, or OCTCN, spontaneous
Ce of any evidence of plaque rupture, OCTerosion, or OCTCN, spontaneous coronary artery dissection (SCAD) (supplemental Figure 2), coronary spasm (supplemental Figure three), and fissure (supplemental Figure 4). Tissue characteristics of underlying plaque have been defined making use of previously established criteria (79). Plaques have been classified as: (i) fibrous (homogeneous, higher backscattering area) or (ii) lipid (lowsignal area with diffuse border). For every lipid plaque, the maximal lipid arc was measured. Lipid length was recorded on a longitudinal view. Thincap fibroatheroma (TCFA) was defined as a plaque with lipid content in 2 quadrants and the thinnest part of the fibrous cap measuring 65 m. Intracoronary thrombus was definedNIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptJ Am Coll Cardiol. Author manuscript; accessible in PMC 204 November 05.Jia et al.Pageas a mass (diameter 250 m) attached towards the luminal surface or floating inside the lumen, which includes red (red blood cellrich) thrombus, defined by higher backscattering and high attenuation, or white (plateletrich) thrombus, defined by homogeneous backscattering with low attenuation. Calcification was defined as an area with low backscattering signal along with a sharp border inside a plaque. Microchannels have been defined as signalpoor voids that had been sharply delineated in a number of contiguous frames (9). Interobserver and intraobserver variability have been assessed by the evaluation of all pictures by two independent observers and by precisely the same observer at two separate time points, respectively. The interobserver Kappa coefficients for thrombus, PR, definite OCTerosion, probable OCTerosion, and OCTCN have been 0.860, 0.885, 0.96, 0.877, and 0.927, respectively. The intraobserver Kappa coefficients for thrombus, PR, definite OCTerosion, probable OCTerosion, and OCTCN were 0.953, 0.952, 0.970, 0.884, and .000, respectively. Quantitative Coronary Angiography (QCA) Coronary angiograms had been analyzed with all the Cardiovascular Angiography Analysis System (CAAS five.0, Pie Medical Imaging B.V Maastricht, The Netherlands). The reference diameter, minimum lumen diameter, diameter stenosis, area stenosis, and lesion length have been measured. Statistical AnalysisNIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptAll statistical analyses had been performed by an independent statistician in the Core Laboratory. Categorical variables had been presented as counts and proportions, as well as the comparisons have been performed making use of a Fisher’s precise test. Continuous variables had been presented as imply typical deviation (SD). The indicates with the continuous measurements were examined using the independent samples ttest for twogroup comparisons, and Evaluation of Variance (ANOVA) for threegroup comparisons (plaque rupture, OCTerosion, and OCTcalcified nodule) followed by posthoc test protected overall significance degree of PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25361489 0.05. A Bonferroni’s correction was applied to control for various comparisons among the 3 groups (plaque rupture, OCTerosion, and OCTcalcified nodule). All statistical analyses had been performed with SPSS 7.0 (SPSS Inc Fatostatin A Chicago, IL). All pvalues were twosided.ResultsBaseline Demographics and Laboratory Results The clinical qualities of classified patients (PR, OCTerosion or OCTCN) and patients with other atypical lesion traits are summarized in Table . There were no important variations in all of the clinical characteristic variables involving the two groups. The comparison of patient charac.
