Oxidative damage in the hippocampus by increasing antioxidant levels in cadmium-exposed rats. BMC Complementary and Alternative Medicine 2014 14:428.Submit your next manuscript to BioMed Central and take full advantage of:?Convenient online submission ?Thorough peer review ?No space constraints or color figure charges ?Immediate publication on acceptance ?Inclusion in PubMed, CAS, Scopus and Google Scholar ?Research which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submit
BMC Clinical PathologyResearch articleBioMed CentralOpen AccessLevels of oxidative stress biomarkers in seminal plasma and their relationship with seminal parametersAli Khosrowbeygi1 and Nosratollah Zarghami*Address: 1Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran and 2Department of Radio Pharmacy, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Email: Ali Khosrowbeygi – [email protected]; Nosratollah Zarghami* – [email protected] * Corresponding author Equal contributorsPublished: 1 June 2007 BMC Clinical Pathology 2007, 7:6 doi:10.1186/1472-6890-7-Received: 9 October 2006 Accepted: 1 JuneThis article is available from: http://www.biomedcentral.com/1472-6890/7/6 ?2007 Khosrowbeygi and Zarghami; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.AbstractBackground: There is growing evidence that damage to spermatozoa by reactive oxygen species (ROS) play a key role in male infertility. The aim of the H 4065 manufacturer present study was to assess seminal plasma levels of total antioxidant capacity (TAC), free 8-Isoprostane and activities of catalase and superoxide dismutase (SOD) in men with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia compared with normozoospermic males. Methods: The patients consisted of 46 men with seminal parameters abnormalities. The patients were grouped into asthenozoospermic (n = 15), asthenoteratozoospermic (n = 16) and oligoasthenoteratozoospermic (n = 15). The control group consisted of 16 healthy males with normozoospermia. Catalase activity was measured by Aebi spectrophotometeric method. Levels of TAC and SOD were measured by commercially available colorimetric assays. Level of free 8Isoprostane was assessed by commercially available enzyme immunoassay (EIA) method. Differences between groups were assessed using Mann-Whitney U test and Kruskal-Wallis test. Coefficients of correlation were calculated using Spearman’s correlation analysis. All hypothesis tests were two-tailed with statistical significance assessed at the PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25768400 p value < 0.05 level with 95 confidence intervals Results: Levels of catalase and TAC were significantly lower in patients than the control group. No significant changes were seen in SOD activities. Levels of free 8-Isoprostane were significantly higher in patients than the control group. Furthermore, asthenozoospermic, asthenoteratozoospermic and oligoasthenoteratozoospermic groups had significantly lower values of catalase activity and TAC when compared to normozoospermic males. Levels of free 8Isoprostane were significantly higher in all patients subgroups than the control group. Levels of catalase and TAC were positively.
