Ross nationwide registers. We used information on date of birth, migration, and socioeconomic status from the civil registration system. Data on morbidity were included from the National Patient Register, holding diagnoses listed Entospletinib custom synthesis according to the international classification of diseases, 8th revision (ICD-8) until 1994, and the 10th revision (ICD-10) thereafter. The National Patient Register contains information on all hospital admissions (since 1978) and outpatient activities (from 1655472 1995) and at discharge each admission is registered by one primary diagnose and, if appropriate one or more secondary diagnoses [17]. The Entospletinib supplier Danish Register of Medicinal Product Statistics (the national prescription register) holds complete information on all prescriptions claimed from Danish pharmacies since 1995, and each prescription is registered according to the international Anatomical Therapeutical Chemical (ATC) classification. As drug expenses in Denmark are partially reimbursed by the government-financed health care system, Danish pharmacies are required to register each dispensed prescription in the national prescription registry, which ensures complete and accurate registration [18]. Deaths are registered in the National Cause of Death Register with one primary, and if appropriate, one or more underlying or contributing causes of death. Socioeconomic status was divided into quintiles, based on mean annual taxed income in the 5 years prior to inclusion.IBD activityHospitalizations with IBD as primary diagnosis, initiation of anti-TNF treatment and dispensed prescription of corticosteroids were used as surrogate markers for disease activity. An IBD flare was defined as a 120 days period starting at the day of initiation of corticosteroid treatment, biological treatment and/or hospitalization for IBD, following 120 days free of corticosteroid prescription or hospitalizations due to IBD (Fig.1) [10]. The first 120 days after study inclusion were likewise defined as a flare period. We further defined periods of persistent activity, as those which succeeded flare periods if additional hospitalizations, anti-TNF treatment or corticosteroid prescriptions had taken place within the 120 days from flare start. Remission periods started 120 days after last hospitalization, anti-TNF treatment or corticosteroid prescription and ended at the time of reinitiating of corticosteroid treatment or hospitalization. We also did sensitivity analyses where corticosteroid prescriptions were excluded as an activity marker.Co-morbidity and medical treatmentWe assessed the presence of co-morbidity at study entry by hospitalization for the following prespecified diagnoses in the 5 years preceding study inclusion (ICD-10 and ICD-8 codes): Cardiac dysrhythmia (I44 49 and 427.3, 427.4, 427.5, 427.6, 427.9), diabetes (E10 14 and 250), chronic obstructive pulmonary disease (J42, J44 and 490?92), renal disease (N03, N04, N17, N18, N19, R34, I12, I13 and 582?88), hypertension (I10?I15 and 400?04), venous thromboembolic disease (I26, I80, I82 and 415, 453 excluding I80.8, I80.0 and I82.0), and heart failure (I42, I43, I50 and 110, 517)._ENREF_19Use of the following drugs (ATC codes) was defined at study inclusion : Glucoselowering agents (A10), statins (C10A), loop diuretics (C03C), platelet inhibitors (B01AC), vitamin K antagonists (B01AA) and we identified patients with hypertension by treatment with at least two of the following classes of antihypertensive drugs: a-adrenergic blocke.Ross nationwide registers. We used information on date of birth, migration, and socioeconomic status from the civil registration system. Data on morbidity were included from the National Patient Register, holding diagnoses listed according to the international classification of diseases, 8th revision (ICD-8) until 1994, and the 10th revision (ICD-10) thereafter. The National Patient Register contains information on all hospital admissions (since 1978) and outpatient activities (from 1655472 1995) and at discharge each admission is registered by one primary diagnose and, if appropriate one or more secondary diagnoses [17]. The Danish Register of Medicinal Product Statistics (the national prescription register) holds complete information on all prescriptions claimed from Danish pharmacies since 1995, and each prescription is registered according to the international Anatomical Therapeutical Chemical (ATC) classification. As drug expenses in Denmark are partially reimbursed by the government-financed health care system, Danish pharmacies are required to register each dispensed prescription in the national prescription registry, which ensures complete and accurate registration [18]. Deaths are registered in the National Cause of Death Register with one primary, and if appropriate, one or more underlying or contributing causes of death. Socioeconomic status was divided into quintiles, based on mean annual taxed income in the 5 years prior to inclusion.IBD activityHospitalizations with IBD as primary diagnosis, initiation of anti-TNF treatment and dispensed prescription of corticosteroids were used as surrogate markers for disease activity. An IBD flare was defined as a 120 days period starting at the day of initiation of corticosteroid treatment, biological treatment and/or hospitalization for IBD, following 120 days free of corticosteroid prescription or hospitalizations due to IBD (Fig.1) [10]. The first 120 days after study inclusion were likewise defined as a flare period. We further defined periods of persistent activity, as those which succeeded flare periods if additional hospitalizations, anti-TNF treatment or corticosteroid prescriptions had taken place within the 120 days from flare start. Remission periods started 120 days after last hospitalization, anti-TNF treatment or corticosteroid prescription and ended at the time of reinitiating of corticosteroid treatment or hospitalization. We also did sensitivity analyses where corticosteroid prescriptions were excluded as an activity marker.Co-morbidity and medical treatmentWe assessed the presence of co-morbidity at study entry by hospitalization for the following prespecified diagnoses in the 5 years preceding study inclusion (ICD-10 and ICD-8 codes): Cardiac dysrhythmia (I44 49 and 427.3, 427.4, 427.5, 427.6, 427.9), diabetes (E10 14 and 250), chronic obstructive pulmonary disease (J42, J44 and 490?92), renal disease (N03, N04, N17, N18, N19, R34, I12, I13 and 582?88), hypertension (I10?I15 and 400?04), venous thromboembolic disease (I26, I80, I82 and 415, 453 excluding I80.8, I80.0 and I82.0), and heart failure (I42, I43, I50 and 110, 517)._ENREF_19Use of the following drugs (ATC codes) was defined at study inclusion : Glucoselowering agents (A10), statins (C10A), loop diuretics (C03C), platelet inhibitors (B01AC), vitamin K antagonists (B01AA) and we identified patients with hypertension by treatment with at least two of the following classes of antihypertensive drugs: a-adrenergic blocke.
