However the role of IGF-1R signaling is not yet well studied in pancreatic cancer cells

s separating illness and health. Based on this we perform a global search using a Genetic Algorithm to find a sequence of externally induced state changes that direct the system to evolve along the most robust trajectory to normal homeostasis. In the case of GWI we show that a sequence of two interventions involving externally applied modulation of Th1 immunity followed by glucocorticoid receptor blockade is potentially capable of delivering sustained relief in a significant proportion of simulated GWI cases. Importantly the strategy presented is not illness specific but can be applied to a broad range of other complex chronic illnesses. Methods Male Model of Neuroendocrine-Immune Interaction Current physiological and biochemical literature describes the HPA, HPG and immune systems as separate entities in great detail, but describes interactions across systems to a much lesser extent. Red nodes denote HC-067047 19668191″ title=View Abstract(s)”>PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19668191 external influences on the system. Green edges are stimulatory, and red edges are inhibitory. This image is a reproduction of the original found in PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19667359 [16] and presented under the PLoS ONE Creative Commons Attribution License. doi:10.1371/journal.pone.0132774.g002 system model incorporating these interactions linking the HPA, HPG and immune systems in males (Fig 2) and in females in order to determine available modes of homeostatic regulation [16]. Our analysis of the control logic governing these systems pointed to sexually dimorphic responses capable of supporting multiple homeostatic modes aligning with both normal health and pathologic dysfunction of the endocrine-immune axis. Experimentally measured biomarker profiles in blood from male GWI subjects showed a preferred alignment of GWI with one of these alternate attractor